IN ORDER TO COPE UP WITH THE CURRENT AND FUTURE MARKET DEMAND
In the pharmaceutical industry, stakeholders are known to adopt a
variety partnership models. Such initiatives not only allow the companies to
expand their respective product / therapy, but also to gain additional
capabilities in emerging technologies. In the domain of TIL-based therapies,
eleven different types of partnership deals were found to be inked between
different stakeholders. These include, acquisition, clinical trial agreement,
joint venture, manufacturing agreement, product development agreement, product
development and commercialization agreement, product licensing agreement,
product supply management agreement, R&D agreement, technology licensing
and others.
During our research, we came across several partnership
agreements, inked during the period 2005-2020 (till October). The number of partnerships has
increased at a CAGR of 53%, between 2014 and 2020. It is important to highlight
that maximum number of partnerships were recorded in 2017, 2018 and 2019,
followed by 2015 (6). Majority of the deals signed in 2016, were R&D
agreements, followed by agreements signed for technology licensing, clinical
trial agreements and manufacturing agreements.
Majority (33%) of the agreements were signed for R&D (13) and
technology and product licensing (8) of TIL-based products. This is followed by
agreements focused on manufacturing (15%), clinical trials and product supply
management, which account for 5% each of the total partnerships inked in this
domain, respectively. Recent examples include the product licensing agreement
signed between Iovance Biotherapeutics and TrakCel in September 2017.[1]
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Funding Initiatives
The technological advancements in this domain, and the promising
results of preclinical / clinical studies of various product candidates have
garnered the attention of several investors. Given the innate advantages
offered by immunotherapeutics, this emerging market has done exceedingly well
in terms of raising funds. The strong and steady performance, in terms of
research-related advances and flow of finances, has been favorable to this
market. Investments from venture capital investors have helped start-ups, such
as Iovance Biotherapeutics and Cellular Biomedicine Group, to become the
current leaders in the TIL-based therapies market.
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Given the current trend, it can be stated that investment from
venture funding rounds is a key enabler for growth in the TIL-based therapies
market. Companies in this domain have raised significant capital through
venture rounds (30%), amounting to USD 68 billion. Some big-ticket investments
include (in decreasing order
of amount) Iovance Biotherapeutics (USD 170 million) and
Cellular Biomedicine Group (USD 10 million). This is followed by secondary
offerings, which account for 24% of the total number of instances, amounting to
USD 1.1 billion. Further, we came across 4 instances of venture capital
investments received by companies from various industrial and non-industrial
organizations. Examples of the players that have received venture capital investments
include (in decreasing order
of amount) Achilles Therapeutics, Instil Bio, PACT Pharma,
Intrexon, KSQ Therapeutics and Phio Pharmaceuticals.
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Contact Details
Ben Johnson
+1 (415) 800 3415
ben.johnson@rootsanalysis.com
Roots Analysis
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